Nicotine, Cotinine and 3-Hydroxycotinine

Feb 15

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2/15/2013 12:00 AM  RssIcon

Weck Laboratory was recently awarded a research contract for analysis of Nicotine and metabolites in biological fluids. The three target analytes: Nicotine, Cotinine and t-3'-Hydroxycotinine are analyzed by direct injection liquid chromatography and electro-spray positive ionization mode tandem mass spectrometry. The laboratory has demontrated direct injection reporting limits for each compound at 1 microgram per liter (ug/L) and method detection limits less than 0.3 ug/L. Environmental water samples can be analyzed with reporting limits approximately 500 times lower limits [2 nanograms per liter (ng/L)] with concentration by solid phase extraction (SPE) technique. Cotinine has been routinely analyzed since the beginning of 2009 with a suite of 38 hormones, pharmaceuticals and personal care products at the low parts per trillion levels (ng/L).

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