Choosing the Best Method for Analysis of 1-4 Dioxane

Sep 15

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9/15/2021 10:40 AM  RssIcon

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EPA 522: Samples are fortified with a surrogate—an isotopically labeled 1,4-dioxane analogue—and concentrated using carbon-based solid phase extraction (SPE). After extraction, the extracts are spiked with an internal standard, analyzed by GCMS, and quantified against an internal standard calibration curve. The recovery of 1,4-dioxane is not corrected for any matrix or extraction inefficiencies, however the surrogate is used to monitor for these potential effects instead. This method should be used for drinking water compliance monitoring.

EPA 8270 SPE: Samples are fortified with the isotopic dilution internal standard—an isotopically labeled 1,4-dioxane analogue—and concentrated using carbon-based solid phase extraction (SPE). After extraction, the extracts are analyzed by GCMS and quantified using the isotopic dilution technique against an internal standard calibration curve. The recovery of 1,4-dioxane is corrected for any matrix or extraction inefficiencies since the internal standard is chemically identical to the target and is carried through the entire extraction process. The use of an isotopically labeled internal standard allows for matrix and extraction inefficiencies correction.

EPA 8270 SPME: Samples are fortified with the isotopic dilution internal standard—an isotopically labeled 1,4-dioxane analogue—and extracted and analyzed using a fully automated liquid handler interfaced with a GCMS. The extraction is performed with a polymeric solid phase microextraction (SPME) fiber, then the fiber is desorbed directly into the inlet of the GC and analyzed by GCMS. 1,4-dioxane is quantified using the isotopic dilution technique against an internal standard calibration curve. The recovery of 1,4-dioxane is corrected for any matrix or extraction inefficiencies since the internal standard is chemically identical to the target and is carried through the entire extraction process. This method offers the analytical advantages of the 8270 SPE method with reduced sample volume requirements. This method is also the “green” choice as is eliminates the use of chlorinated solvents.

Analytical Method Details - Weck Laboratories, Inc.
Method MRL Units Containers/Volume Preservation Holding Time
1,4-Dioxane by SPE/GCMS SIM, EPA Method 522
0.07
ug/L
Two - 125-mL Amber Glass
 <6°C, Sulfite/Bisulfate, pH<3
28
1,4-Dioxane Low Level by Isotopic Dilution SPME-GC/MS 8270M
0.5 ug/L Two - 40-mL Amber VOAs
<6°C, Na2S2O3 (If Cl2)
7
1,4-Dioxane Low Level by Isotopic Dilution GC/MS 8270M
0.5 ug/L Two - 500-mL Amber Glass
<6°C, Na2S2O3 (If Cl2)
7



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